At MiNDSET, we’ve always grounded our care in clinical evidence and medical oversight—not in trends. The recent Neuropharmacology study by Prochazkova and colleagues (2025) underscores why that distinction matters.
The Science Speaks: No Real Benefits from Microdosing
In two double-blind, placebo-controlled trials, researchers examined the cognitive and emotional effects of microdosing psilocybin—the active compound in “magic mushrooms.” The results? No measurable improvement in mood, attention, memory, or well-being compared to placebo. Participants who believed they were taking psilocybin often reported positive experiences, but those effects vanished once the placebo factor was accounted for.
These findings challenge the popular belief that microdosing enhances focus or creativity. Instead, they highlight what clinicians have long known: expectation often drives experience more than chem
Why MiNDSET Takes a Different Approach
At MiNDSET, our stance has always been clear—psychedelic therapy should be conducted under the direct supervision of a board-certified physician, in a controlled medical environment. Self-experimentation through microdosing may seem low-risk, but it carries real uncertainties: unregulated compounds, inconsistent potency, and unknown neurochemical effects over time.
In contrast, intravenous (IV) ketamine therapy is a proven, physician-led treatment for severe depression, anxiety, PTSD, and chronic pain. Backed by extensive clinical research, IV ketamine has shown a 65–70% response rate and can produce measurable relief within hours, not weeks. At MiNDSET, we pair each infusion with psychotherapy to help patients process and sustain their breakthroughs—an integrative model that has yielded outcomes far beyond what medication alone can achieve.
Our Commitment: Evidence Over Fad
While social media might celebrate microdosing as a “productivity hack,” science continues to show that placebo effects, not pharmacology, are driving the perceived benefits. At MiNDSET, we choose a higher standard—medical safety, evidence-based treatment, and measurable results for those facing serious mental health challenges.
Psychedelic therapy is not about chasing novelty. It’s about restoring health, clarity, and connection through clinical integrity and compassionate care.
That’s the MiNDSET difference.
